I See Mantle Cell Lymphoma

“I See Mantle Cell Lymphoma” is a dedicated resource to help you find the latest information about the signs, symptoms, diagnoses and treatment of MCL.

WHAT IS MANTLE CELL LYMPHOMA?

Mantle cell lymphoma (MCL) is a relatively unique subcategory of B-cell non-Hodgkin's lymphoma (NHL) with a generally aggressive clinical course.¹

MCL develops from changes to the outer edge, or mantle, of lymph nodes causing the development of abnormal B-cells from that region.² Generally, patients have stage III/IV disease and present with extensive lymphadenopathy, blood and bone marrow involvement, and splenomegaly.³

The decision to start treatment, along with treatment selection, takes several factors into account, including the age and relative fitness level of patients.^2,4 Although the boundaries are not clear-cut, intensive therapies are generally reserved for younger and fitter patients, and non-intensive therapies for older or more frail patients.²

Here, we present an overview of the prevalence, diagnostic process and clinical presentation of MCL.

An infographic stating that WM makes up 1–2% of non-Hodgkin lymphoma cases, 60–75 years is the median age at WM diagnosis, and WM is twice as common in men as it is in women.

Understand how MCL is diagnosed

References:

Jain P and Wang M. Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management. Am J Hematol 2019;94:710–25.
Leukemia & Lymphoma Society. Mantle cell lymphoma facts. Available at: https://www.llscanada.org/sites/default/files/National/CANADA/Pdf/InfoBooklets/FS4_MCL_2018_FINAL.pdf. Accessed August 24, 2021.
Vose J. Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management. Am J Hematol 2017;92:806–13.
Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for B-Cell Lymphomas V.1.2022 – March 2, 2022. © National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed March 4, 2022. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.